Advances in Genomic Medicine (B-KUL-E0H83A)

5 ECTSEnglish30 First termCannot be taken as part of an examination contract
Vermeesch Joris (coordinator) |  Borry Pascal |  Cleynen Isabelle |  Matthijs Gert |  Van Hoyweghen Ine |  Vanden Bempt Isabelle |  Vermeesch Joris |  N. |  Van Den Bogaert Kris (substitute) |  Dewaele Barbara (cooperator)  | LessMore
POC Biomedische wetenschappen

Please do not select a Research Track via your ISP, but use the application of the Faculty to apply for these elective courses. Students are asked to rank their choice of elective course and students are distributed amongst the available places in each Research Track by an allocation tool. Each research track has a limited number of students that can enroll for a course in order to facilitate interactive teaching. More information about this procedure will follow in the first week of the academic year.

Students from another Faculty or programme who wish to participate in a Research Track will need to submit an application via the following form. Only if the maximal number of students per Research Track is not yet reached, students from other programmes can be admitted. More information regarding this procedure and the conditions for applying for these courses can be consulted via the website/form.

If there aren't enough applications for a Research Track, students will be contacted and asked to choose another Research Track.

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After finishing this course, the students will be able to:

- Know the concepts of all aspects of Genomic Medicine
- Know the different application domains including constitutional rare disease diagnosis, cancer diagnosis, personalized genomics.  
- Understand the challenges of implementing personalized genomics
- Critically analyze what a diagnosis or risk means, understand the opportunities and the pitfalls.
- Describe how omics technologies are exploited for preventing or curing human diseases.
- Identify the innate relationship between the genome and the pathophysiology of a disease.
- Examine the various strategies for exploiting genomics to improve disease management and therapy application.
- Incorporate their previously acquired knowledge on molecular cell biology, biochemistry and/or genetics with biomarker analyses.
- Know about ongoing data sharing initiatives and future perspectives for health.
- Understand the ethical issues involved with personal medicine.
 

Students attending this course should have basic knowledge of molecular or cell biology, genetics and/or biochemistry. Knowledge on basic concepts behind human diseases & medicine could be advantageous but is not mandatory.

Mixed prerequisite:
You may only take this course if you comply with the prerequisites. Prerequisites can be strict or flexible, or can imply simultaneity. A degree level can be also be a prerequisite.
Explanation:
STRICT: You may only take this course if you have passed or applied tolerance for the courses for which this condition is set.
FLEXIBLE: You may only take this course if you have previously taken the courses for which this condition is set.
SIMULTANEOUS: You may only take this course if you also take the courses for which this condition is set (or have taken them previously).
DEGREE: You may only take this course if you have obtained this degree level.


FLEXIBLE(E08C5D) OR FLEXIBLE(U04D3A)

The codes of the course units mentioned above correspond to the following course descriptions:
E08C5D : Bachelorproef
U04D3A : Bachelorproef

This course unit is a prerequisite for taking the following course units:
E0H84A : Hot Topics in Genomic Medicine

Activities

5 ects. Advances in Genomic Medicine (B-KUL-E0H83a)

5 ECTSEnglishFormat: Lecture30 First term
POC Biomedische wetenschappen

Lectures (of approximately 3 h each) will be given by different teachers on the following topics:

1. Genomic Medicine: Introduction
2. Medical Omics technologies
3. Rare Diseases
4. Omics diagnosis: hands on
5. Cancer Omics
6. Cancer omics hands on   
7. Pharmacogenomics & carrier screening
8. Polygenic risk scores and clinical implementation
9. Clinical/counseling aspects of Medical Genomics/counseling   
10. Ethical challenges
11. Large scale data sharing initiatives, Genomics for all, 1+MG.

 

- Genetics and Genomics in Medicine (Tom Strachan, Garland Science)
- Toledo (Course material e.g. presentations & reference materials e.g. research/review papers)

Evaluation

Evaluation: Advances in Genomic Medicine (B-KUL-E2H83a)

Type : Continuous assessment without exam during the examination period
Description of evaluation : Participation during contact hours, Take-Home
Type of questions : Open questions
Learning material : Course material, Computer, Reference work


Exam:

- Every teacher will convey 1 open questions for a take-home assignment.
- Each student will receive 1 question per lecture (questions can/will be grouped).
- Each teacher will grade the answers to his/her assignments.
- The final score per student will be the average of all scores from all the teachers.
- If no assignment is turned in for particular teacher(s), the student will receive a score of 0/20 for those teachers.

Attendance at the lectures: Attendance at all the lectures is mandatory. In case of absence, the student is nevertheless expected to turn in an answer (since respective powerpoint presentations, review materials & questions for each lecture will be available for access). If a student fails to turn-in his/her answers within the stipulated deadline, then this will automatically result in a zero score for the concerned teacher(s).