Advances in Oncology – Focus on Molecular Mechanisms (B-KUL-E09F8A)

5 ECTSEnglish30 First termCannot be taken as part of an examination contract
Marine Chris (coordinator) |  Marine Chris |  Mazzone Max |  Scheele Colinda |  N. |  Leucci Eleonora (substitute) |  Bergers Gabriele (substitute)  | LessMore
POC Biomedische wetenschappen

Please do not select a Research Track via your ISP, but use the application of the Faculty to apply for these elective courses. Students are asked to rank their choice of elective course and students are distributed amongst the available places in each Research Track by an allocation tool. Each research track has a limited number of students that can enroll for a course in order to facilitate interactive teaching. More information about this procedure will follow in the first week of the academic year.

Students from another Faculty or programme who wish to participate in a Research Track will need to submit an application via the following form. Only if the maximal number of students per Research Track is not yet reached, students from other programmes can be admitted. More information regarding this procedure and the conditions for applying for these courses can be consulted via the website/form.

If there aren't enough applications for a Research Track, students will be contacted and asked to choose another Research Track.

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Cancer develops when gradual irreversible genetic or epigenetic changes accumulate in a cell and transform the cellular proteome in a way that a malignant cellular phenotype can develop. Typical characteristics of the malignant cellular phenotype are: unrestricted and autonomous cell growth, unlimited cell proliferation, resistance to apoptosis, tissue invasion and induction of angiogenesis and genetic instability. In ‘Advances in Oncology II’, important concepts of cell biology, experimental approaches and therapeutic principles of malignant diseases are considered in detail, by means of recent reviews in the literature.
 
After this course, students are considered to be able to:
- comment on modern insights in selected topics and discuss them
- read and understand reviews about related topics that were not discussed
- put original articles about selected topics in the right scientific context

Mixed prerequisite:
You may only take this course if you comply with the prerequisites. Prerequisites can be strict or flexible, or can imply simultaneity. A degree level can be also be a prerequisite.
Explanation:
STRICT: You may only take this course if you have passed or applied tolerance for the courses for which this condition is set.
FLEXIBLE: You may only take this course if you have previously taken the courses for which this condition is set.
SIMULTANEOUS: You may only take this course if you also take the courses for which this condition is set (or have taken them previously).
DEGREE: You may only take this course if you have obtained this degree level.


FLEXIBLE(E08C5D) OR FLEXIBLE(U04D3A)

The codes of the course units mentioned above correspond to the following course descriptions:
E08C5D : Bachelorproef
U04D3A : Bachelorproef

This course unit is a prerequisite for taking the following course units:
E09F9A : Hot topics in Oncology – Focus on Molecular Mechanisms

Activities

5 ects. Advances in Oncology – Focus on Molecular Mechanisms (B-KUL-E09F8a)

5 ECTSEnglishFormat: Practical30 First term
Marine Chris |  Mazzone Max |  Scheele Colinda |  N. |  Leucci Eleonora (substitute) |  Bergers Gabriele (substitute)  | LessMore
POC Biomedische wetenschappen

This course focuses on the mechanisms by which cancer-specific mutational and non-mutational (i.e. epigenetic and (post-)transcriptional) events modulate tumor initiation, progression and therapy outcome. A deep dive into several mechanistic aspects of cancer biology is proposed, and in particular, in the identification of cancer initiating and propagating (i.e. cancer stem) cells and the mechanisms that contribute to early tumor development, emergence of inter- and intra-tumor heterogeneity and therapy resistance. We will revisit the importance of key oncogenic and tumor suppressor pathways (i.e. p53, NF-KP, RAS, …) and study mechanisms controlling their activities, discuss the contribution of the non-coding genome and the tumor microenvironment as modulators of cancer progression, and the importance of epigenetic and other non-genetic mechanisms as drivers of intra-tumor heterogeneity, plasticity and therapy failure.

Articles and literature
Slides
E-platform

Evaluation

Evaluation: Advances in Oncology – Focus on Molecular Mechanisms (B-KUL-E29F8a)

Type : Exam outside of the normal examination period
Description of evaluation : Written


Exam
This course will be evaluated in the form of a written exam that will take place during the exam period after the 1st semester. 

Attendance at the lectures
Attendance at the classes is strongly recommended.

Third examination period
The evaluation during the third exam period is the same as above.