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Optional in stage
First term
Second term
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This year
Next year
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Prerequisites
Taught by
Language of instruction
Duration
Identical coursesAims
The students will be confronted with general synthetic strategies (protection, deprotection, synthons, retrosynthetic analysis, selectivity), during which the latest evolutions in this domain will be brought to their attention. Focus will mainly be on heterocyclic chemistry and biologically active or industrially relevant products. Eventually, the students should be able to tackle complex synthetic problems in a strategic way.
Previous knowledge
Organic chemistry BA2, Adganced organic chemistry MA1
Is included in these courses of study
Activities
6 ects. Synthetic Strategies (B-KUL-G0I01a)
Content
General principles: retrosynthetic analysis, synthons, protecting/deprotecting, “umpolung”
Heterocyclic compounds: synthesis and properties (e.g. basicity, tautomery, reactivity)
Modern methods to functionalise organic molecules: mainly oxidation and reduction reactions.
Regio- and stereoselectivity of organic reactions
Synthesis on a solid carrier
Some examples of total syntheses
Course material
Course text (found on Toledo)
Powerpoint slides (Toledo)
Language of instruction: more information
no comments
Evaluation
Evaluation: Synthetic Strategies (B-KUL-G2I01a)
Explanation
Exam consists of exercices (open questions)