Required in stage
Optional in stage
First term
Second term
Both terms
Not organised
This year
Next year
Alternating years
External
Prerequisites
Taught by
Language of instruction
Duration
Identical coursesAims
This course is aimed at:
- familiarizing students with basic concepts concerning the medical-diagnostic use of radioactive links;
- imparting thorough knowledge of the chemical and physical qualities, the mode of preparation, the analysis and the applications of radiopharmaca for in vivo diagnostic and therapeutic use;
- imparting insight into the pharmacokinetics of the distinguished radiopharmaca;
- imparting thorough knowledge of the different contrast-raising products used in case of radiological research by means of X-rays and in case of magnetical resonation tomography and echography.
Previous knowledge
No specific prior knowledge required.
Is included in these courses of study
Activities
3 ects. Radiopharmacy (B-KUL-G0T92a)
Content
Radiopharmaceuticals
- Regulations concerning radiopharmaca.
- Concepts of nuclear physics and measuring of radioactivity: definition of a radioisotope, types of radioisotopes and their decline, qualities of ionising radiation, interaction of molecules with matter, filmdosimeter, ionisation room, NaI(Tl) detectors, gammaspectrometry, production of radioisotopes.
- Analysis techniques used in the analysis of radiopharmaca (HPLC, gell permeation chromatography, thin-layer chromatography, electrophoresis).
- Production of radionuclides in nuclear reactors and cyclotrons, operating of generators (a.o. 99Mo-99mTc generator, 81mKr generator).
- General concepts with regards to complexation of radionuclides.
- Discussion of radiopharmaca (including production, analysis, biological behaviour, indications): radiopharmaca for therapeutical use: 131I-NaI, 131I-MIBG, 32P-Natriumhosphate, radiopharmaca for palliative treatment of skeleton metastases, marked antibodies, 90Y-colloïedes, radiopharmacafor diagnostical use: marked with 201Tl; marked with 67Ga; marked with 111In; marked with 123I, 125I, 131I; marked with 51Cr; marked with 99mTc(including 99Mo/99mTc generator, marking methods, preparation marking kitten); marked with 57Co and 58Co; PET-radiopharmaca (marked with 18F, 11C, 13N, 15O); 81mKr gass.
- Dosimetry, specific problems and side-effects of radiopharmaca.
Contrast-raising products
- Survey of contrast substances used in radiological research by means of X-rays.
- Survey of contrast-raising substances used in magnetical Overzicht resonance tomography.
- Survey of contrast-raising substances in echography.
Course material
Text book
Syllabus
Manual
Slides, transparencies, courseware