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LevelNMR Spectroscopy and Molecular Modelling (B-KUL-K05D5A)
Aims
This series of lecture is offerred as introduction to the possibilities and shortcommings of NMR spectroscopy and molecular modelling.
The goals are:
Interpratation of simple NMR-spectra and judge NMR methods used in publications that contain NMR structure determination
Search and retrieve a structure from the PDB-database
Recognize structural elements in a three dimensional structure and interactions between molecules in a complex Obtain basic knowledge on how computer programs can use experimental data to calculate a molecular model with applications in drug design.
Previous knowledge
Basic knowledge in organic chemistry an biochemistry is required. Student should have a notion on general physics, electromagnetism and mathematics.
Course material
Articles and literature
Syllabus
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Toledo / e-platform
Is also included in other courses
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Master in de farmaceutische zorg
120 ects.
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Master in de geneesmiddelenontwikkeling
120 ects.
-
Postgraduate Studies in Pharmaceutical Research
60 ects.
Activities
3.0 ects. NMR Spectroscopy and Molecular Modelling (B-KUL-K05D5a)
Content
Introduction on the NMR-principles including properties and interactions between NMR-active nuclei. Common one and two dimensional NMR experiments are explained using an example.
Introduction to the physicochemical background of molecular interactions and how the latter are used in drug design by molecular modeling.
Description of learning activities
Lecture + Assigments (Toledo)
Course material
Articles and literature
Course text
Slides
Toledo
