B-KUL-E04N5A Fundamental and Medical Aspects of Cardiovascular Biology

Show all details |  Hide all details

General information

Academic year: 2011-2012 Study points: 5 Language: English Difficulty: Advanced Duration: 30.0 hours  Periodicity: Taught in the first semester POC: POC Biomedische wetenschappen This course cannot be followed within the context of an exam contract

Print version

Taught by

Dewerchin Maria (coordinator)
Carmeliet Peter
Chuah Marinee
De Geest Bart
Dewerchin Maria
Freson Kathleen
Hoylaerts Marc
Janssens Stefan
Lambrechts Diether
Lijnen Henri
Luttun Aernout
Vandendriessche Thierry

Aims

This Advanced course will give a thorough overview of cardiovascular biology and disease, discussing fundamental, diagnostic, as well as therapeutic issues.  
Appropriate attention is given to the integration of state-of-the-art gene/genome and downstream transcriptome or proteome technologies as well as to the experimental in vitro and in vivo models, each with its possibilities, advantages and drawbacks, that are applied to unravel the molecular and cellular pathways and identify candidate genes involved in the pathophysiological processes discussed.

Previous knowledge

Celbiologie, moleculaire biologie, genetica
 
You should not indicate these choices in your ISP, but these should go through the choice program of the Faculty. More info on this will follow during the first week of the academic year. The final allotment of these courses will be done by the Faculty and announced on Toledo. The maximum number of students that can participate per research track is 25. Students from other faculties who wish to take one of the subjoined courses should submit a request at Anouk Desmet.
Only when the maximum number of students per research track has not been reached, students are permitted.

Content

The following topics will be taught by a team of lecturers that are 
expert in the corresponding clinical and/or basic research topic.

• Extracellular
  proteinases: key roles in fibrinolysis, thrombolysis and 
  atherosclerosis
  
• Haemostasis: platelet adhesion and signal 
  transduction, haemostatic regulation, thrombosis, bleeding disorders
  
• Angiogenesis:
  blood vessel formation and underlying cellular and molecular 
  mechanisms, novel angiogenic therapeutic strategies
  
• Lymphangiogenesis:
  formation of the lymphatic system and underlying cellular and molecular
  mechanisms, lymphangiogenesis in health and disease
  
• Links 
  between vessels and nerves: role of key angiogenesis signals in the 
  nervous system, therapeutic potential of angiogenic molecules in 
  neurodegenerative disease (ALS, MS PD), role of angiogenesis molecules 
  as axon guidance signals, role of axon guidance cues as vessel 
  navigation signals
  
• Vessel wall biology and disease: cellular and
  molecular pathways underlying atherosclerosis, cholesterol, 
  lipoproteins and atherosclerosis, therapeutic approaches
  
• Cardiac
  biology: ischemic injury, cardioprotection and repair, cardiac 
  hypertrophy and heart failure, cardiac remodeling, current therapeutic 
  advances in cardiovascular disease (drugs, biologicals, and stem cells)
  
• Gene
  therapy and stem cell bioengineering in cardiovascular disease: 
  development and characterization of gene delivery vectors, preclinical 
  and clinical studies
  
• Adult stem cells (MAPC) to study vascular 
  differentiation and regeneration
  
• Genetic screening of patients 
  with cardiovascular disease: gene-specific screening and 
  disease-specific screening to test the relevance of experimental 
  findings to the patient situation, and to identify novel disease 
  candidate genes

This course is included in

Master of Science in Biomedical Sciences  
Master of Science in de biomedische wetenschappen   (Afstudeerrichting Onderzoek in de biomedische wetenschappen)

Course Material

Articles and literature
Slides, transparencies, courseware
Toledo / e-platform

Prerequisites

Mixed prerequisite:
If you want to take this course, you need to fulfil the following prerequisites:
Explanation:
STRICT: If you want to take this course, you need to have passed or used a tolerance for the coures indicated here.
SMOOTH: If you want to take this course, you need to have attended the courses indicated here.
SIMULTANEOUS: If you want to take this course, you need to take / need to have taken the courses indicated here.
DIPLOMA: If you want to take this course, you need to have obtained at least one of the diplomas indicated here.

DIPLOMA( 50074173 )

The codes of the courses (or diplomas) correspond with the descriptions beneath:
50074173:  Bachelor of Science in de biomedische wetenschappen

This course is a prerequisite for the following courses:
E04N6A:  Hot Topics in Fundamental and Medical Aspects of Cardiovascular Biology

Activities

		B-KUL-E04N5a Fundamental and Medical Aspects of Cardiovascular Biology
	General information Study points: 5.00 Language: English Category: Seminars Duration: 30.0 hours  Periodicity: Taught in the first semester POC: POC Biomedische wetenschappen Taught by Carmeliet Peter Chuah Marinee De Geest Bart Dewerchin Maria Freson Kathleen Hoylaerts Marc Janssens Stefan Lambrechts Diether Lijnen Henri Luttun Aernout Vandendriessche Thierry Aims This Advanced course will give a thorough overview of  cardiovascular biology and disease, discussing fundamental, diagnostic,  as well as therapeutic issues.   Appropriate attention is given to  the integration of state-of-the-art gene/genome and downstream  transcriptome or proteome technologies as well as to the experimental in vitro and in vivo models, each with its possibilities, advantages and  drawbacks, that are applied to unravel the molecular and cellular  pathways and identify candidate genes involved in the pathophysiological processes discussed. Content The following topics will be taught by a team of lecturers that are expert in the corresponding clinical and/or basic research topic. Extracellular proteinases: key roles in fibrinolysis, thrombolysis and atherosclerosis Haemostasis: platelet adhesion and signal transduction, haemostatic regulation, thrombosis, bleeding disorders Angiogenesis: blood vessel formation and underlying cellular and molecular mechanisms, novel angiogenic therapeutic strategies Lymphangiogenesis: formation of the lymphatic system and underlying cellular and molecular mechanisms, lymphangiogenesis in health and disease Links between vessels and nerves: role of key angiogenesis signals in the nervous system, therapeutic potential of angiogenic molecules in neurodegenerative disease (ALS, MS PD), role of angiogenesis molecules as axon guidance signals, role of axon guidance cues as vessel navigation signals Vessel wall biology and disease: cellular and molecular pathways underlying atherosclerosis, cholesterol, lipoproteins and atherosclerosis, therapeutic approaches Cardiac biology: ischemic injury, cardioprotection and repair, cardiac hypertrophy and heart failure, cardiac remodeling, current therapeutic advances in cardiovascular disease (drugs, biologicals, and stem cells) Gene therapy and stem cell bioengineering in cardiovascular disease: development and characterization of gene delivery vectors, preclinical and clinical studies Adult stem cells (MAPC) to study vascular differentiation and regeneration Genetic screening of patients with cardiovascular disease: gene-specific screening and disease-specific screening to test the relevance of experimental findings to the patient situation, and to identify novel disease candidate genes   Course Material Articles and literature Slides, transparencies, courseware Toledo / e-platform   Course activities Lectures and interactive discussions of articles

Evaluation

		B-KUL-E24N5a Evaluation : Fundamental and Medical Aspects of Cardiovascular Biology
	Evaluation description Examination type:     written When?: evaluation outside normal examination period Evaluation type:     Closed book